“Every
time I started to walk I would feel like I was walking on marbles. Slowly my
legs would start becoming numb, and the numbness would slowly move up my legs,
and then shocks would rack my body head to toe whenever I bent my head forward.”
“I
started to get very itchy in my arm for weeks and it was followed by my legs
turning heavy and weak, and overall feeling of fatigue.”
“Blinding
headaches that lasted for days before I developed the numbness and the tingling
of various body parts, was my first introduction to this condition. The bath
water being warm on one foot and cold on the other made me seek the doctor.”
“I was
7 when out of the blue the right side of my face went numb and I started
slurring my speech.”
“The
first noticeable symptom was hip trouble, it was excruciatingly painful in
certain positions, then came the inability to hold a pen/pencil; my writing
became more and more childlike followed by my leg feeling literally glued to the floor - all this while I experienced a
prickly heat sensation in my lower legs and my thighs.”
The
above statements are but a few instances of symptoms suffered by people who
were later diagnosed to have MULTIPLE SCLEROSIS.
Multiple sclerosis (MS) is an autoimmune
disease in which the nerves of the central nervous system namely, the brain and
the spinal cord degenerate. The myelin sheath, a protective covering that surrounds the
nerve cells and provides insulation
and thereby improves the conduction of impulses along the nerves and
maintains the health of the nerves disappear
in the case of a person with MS.
What causes multiple sclerosis?
The cause of Multiple Sclerosis is still eluding researchers
and doctors. The immune system defends an aggressor or a foreign object by
mounting a defensive action which identifies and attacks the invader and then
withdraws. In the case of a person affected by MS a foreign agent such as a
virus alters the immune system such that the immune system perceives myelin as
an intruder and attacks it. While some of the myelin may be repaired after the
assault, some of the nerves are stripped of their myelin covering. Scarring
also occurs, and the material is deposited into the scars forming
plaques.
Although its role is unclear, statistics suggest that
genetic factors play a major role in multiple sclerosis. However, other data
suggest that environmental factors also play an important role.
What are the types of multiple
sclerosis?
There are different clinical
manifestations of multiple sclerosis.
During an attack, a person
experiences a sudden deterioration in normal physical abilities that may range from
mild to severe. This attack, sometimes referred to as an exacerbation of multiple sclerosis, typically lasts
more than 24 hours and generally more than a few weeks.
About 65%-80% of individuals begin
with relapsing-remitting (RR) MS, the most common type. In
this type, they experience a series of attacks followed by complete or partial
disappearance of the symptoms (remission) until another attack occurs
(relapse). It may be weeks to decades between relapses.
In primary-progressive (PP) MS,
there is a continuous, gradual decline in a person's physical abilities right from
the outset rather than relapses. About 10%-20% of individuals begin with PP-MS.
Those beginning with RR-MS can then
enter a phase where relapses are rare but more disability accumulates, and are
said to have secondary-progressive (SP) MS.
About 50% of RR-MS individuals will develop SP-MS within 10 years. Over several
decades, most RR-MS persons will experience progression to SP-MS.
Progressive-Relapsing (PR) MS is a
type of multiple sclerosis characterized by a steady decline in abilities
accompanied by sporadic attacks. There are cases of multiple sclerosis that are
mild and can be recognized only retrospectively after many years and also rare
cases of extremely rapid progression of multiple sclerosis symptoms (sometimes
fatal) known as malignant or fulminant (Marburg variant) multiple sclerosis.
What are the symptoms of multiple
sclerosis?
Symptoms of multiple sclerosis may be single or multiple and
may range from mild to severe in intensity and short to long in duration.
Complete or partial remission from symptoms occurs early in about 70% of
individuals with multiple sclerosis.
·
Visual disturbances may be the first
symptoms of multiple sclerosis, but they usually subside.
·
Limb weakness with or without
difficulties of coordination and balance may occur early.
·
There may be a loss of sensation,
speech impediment (typically a problem articulating words), tremors, or dizziness.
·
decreased concentration,
·
attention deficits,
·
inability to perform sequential
tasks, or
·
impairment in judgment.
·
paranoia, or
·
an uncontrollable urge to laugh and
weep.
As the disease progresses, individuals may experience sexual
dysfunction or reduced bowel and bladder control.
What are the types of tests
available for multiple sclerosis?
Due to the broad range and subtleties of symptoms, multiple
sclerosis may not be diagnosed for months to years after the onset of symptoms.
Physicians, particularly neurologists, take detailed histories and perform
complete physical and neurological examinations.
·
MRI (magnetic resonance
imaging) scans with intravenous gadolinium helps to identify,
describe, and in some instances date lesions in the brain (plaques).
·
An electro-physiological test,
evoked potentials, examines the impulses traveling through the nerves to
determine if the impulses are moving normally or too slowly.
·
Finally, examining the
cerebro-spinal fluid that surrounds the brain and spinal cord may identify
abnormal chemicals (antibodies) or cells that suggest the presence of multiple
sclerosis.
Collectively, these three tests help the physician in
confirming the diagnosis of multiple sclerosis.
What are the treatments available
for multiple sclerosis?
There are many issues for the
patient and physician to consider in treating multiple sclerosis. Goals may
include:
·
improving the speed of recovery from
attacks (treatment with steroid drugs);
·
reducing the number of attacks or
the number of MRI lesions; or
·
attempting to slow progression of
the disease (treatment with disease modifying drugs or DMDs).
An additional goal is relief from complications due to the
loss of function of affected organs (treatment with drugs aimed at specific
symptoms).
Most neurologists will consider treatment with DMDs once the
diagnosis of relapsing remitting multiple sclerosis is established. Many will
begin treatment at the time of the first multiple sclerosis attack, since
clinical trials have suggested that patients in whom treatment is delayed may
not benefit as much as patients who are treated early.
Finally, utilizing support groups or counseling may be
helpful for patients and their families whose lives may be affected directly by
multiple sclerosis.
Once goals have been set, initial therapy may include
medications to manage attacks, symptoms, or both. An understanding of the
potential side effects of drugs is critical for the patient because sometimes
side effects alone deter patients from drug therapy. Patients may choose to
avoid drugs altogether or choose an alternative drug that may offer relief with
fewer side effects. A continuous dialogue between the patient and physician
about the medications is important in determining the needs for treatment.
Multiple Sclerosis At
A Glance
·
Multiple
sclerosis (MS) is a disease which progressively injures the nerves of the brain
and spinal cord.
·
Injury
to the nerves in multiple sclerosis may be reflected by alterations of
virtually any sensory or motor (muscular) function in the body.
·
The
cause of multiple sclerosis is unknown, but it has become widely accepted that
genetic, immunological, and environmental factors play a role.
·
The
selection of drug treatment/therapy should be made after the patient with
multiple sclerosis has been properly informed of drug efficacy, particular
FDA-approved uses, administration routes, risks of adverse events, and methods
to enhance tolerability and compliance.